Kadar Cea dan Ca 19-9 Dalam Serum Berdasarkan Differensiasi Sel pada Kanker Kolorektal

Abstract

Background --- Carcinoembryonic antigen (CEA) and Carbohydrate antigen (CA 19-9) are the most common tumor markers for colorectal cancer. Both have prognostic value. Recommendation by the Colorectal Working Group of the American Joint Committee on Cancer (AJCC) that elevated CEA level (defined as ≥ 5 μg/l and elevated CA 19-9 (defined as ≥ 37 U/ml). Objective --- To evaluate different serum level of CEA and CA 19-9 based on cell differentiation in colorectal cancer. Materials and Methods --- The study sample was patients (n= 40, 50.78 ± 14.96 years old, 22 males, 18 females) between July 2012 until May 2013 measurement of CEA and CA 19-9. Clinicopathological characteristics and associated follow-up data were cross sectional with comparative analytic. Then to evaluate different and correlation serum level of CEA and CA 19-9 based on cell differentiation (histopathologic grading). Result --- Serum level of CEA and CA 19-9 based on cell differentiation were not significantly different. Score result p value 0,314 (p > 0,05) and p value 0,787 (p > 0,05). There was not correlation of CEA and CA 19-9 based on cell differentiation p value 0,475 (P > 0,05) dan p value 0.247 ( p > 0,05). Conclusion --- Level of both CEA and CA 19-9 have not significantly different based on cell differentiation in colorectal cancer.

Latar Belakang --- Carcinoembryonic Antigen (CEA) dan Carbohydrate Antigen (CA 19-9) adalah penanda tumor untuk kanker kolorektal (KKR). Keduanya memiliki nilai prognostik. Berdasarkan Colorectal Working Group of the American Joint Committee on Cancer dikatakan nilai abnormal bila peningkatan nilai CEA yaitu ≥ 5 μg/l dan peningkatan nilai CA 19-9 yaitu ≥ 37 U/ml. Tujuan --- Untuk mengetahui perbedaan kadar CEA dan CA 19-9 dalam serum berdasarkan differensiasi sel yang berbeda pada KKR. Bahan dan Cara --- Sampel studi adalah pasien KKR (n = 40, rerata umur SD 54,67 ± 14,96, 22 pria, 18 wanita) antara Juli 2012 sampai dengan Mei 2013 diperiksa kadar serum CEA dan CA 19-9. Karakteristik klinikopatologis dan data dasar diperoleh secara cross sectional dengan analisis komparatif. Selanjutnya dianalisis perbedaan serta korelasi kadar CEA dan CA 19-9 berdasarkan differensiasi sel (derajat histopatologi). Hasil --- Kadar serum CEA dan CA 19-9 pada KKR berdasarkan differensiasi sel tidak dijumpai perbedaan bermakna yaitu p value 0,314 (p >0,05) dan p value 0,787 (p > 0,05). Uji Chi-square dan Spearman didapatkan hasil tidak dijumpai hubungan yang significant antara CEA dan CA 19-9 dengan differensiasi sel yaitu p value 0,475 (p > 0,05) dan p value 0,247 (p > 0,05).