Penilaian Kadar Fibrinogen pada Subjek Sindroma Metabolik dan Obesitas

Abstract

Background: Fibrinogen plays an important role in the process of thrombosis both primary (platelets aggregation) and secondary (blood coagulation), and also play a role in increasing blood viscosity thus spur the process of the formation of the plaques ateromatous and thrombosis. Aim : To see the differences in the fibrinogen levels on the subject of metabolic syndrome and obesity. Method: This cross-sectional study was carried out with observational analytic approach, in Department of internal medicine division Endocrine RSUP H. Adam Malik Medan, February-April 2013, in 15 subject with metabolic syndrome and 15 subject with obesity Results: In our study the mean level of fibrinogen on the SM group was (542.9± 209.3) and obese group was (503.5 ± 192.8), but not significantly different with (p=0.633). And also there was no correlation between fibrinogen levels with metabolic syndrome components Conclusion: There are increased of Fibrinogen levels in metabolic syndrome group compared with obese group, although there was no significantly difference. There is no correlation between the fibrinogen levels and metabolic syndrome component.

Latar Belakang : Fibrinogen memegang peranan penting pada proses thrombosis baik primer (agregasi thrombosit) maupun sekunder (koagulasi darah), juga berperan dalam meningkatkan viskositas darah sehingga memacu proses terbentuknya plak ateromatous dan selanjutnya thrombosis. Tujuan : Untuk melihat perbedaan kadar fibrinogen pada subjek sindroma metabolik dan obesitas. Metode : Studi cross sectional ini dilakukan dengan metode observational analitik, di Poli Penyakit Dalam bagian Endokrin RSUP H Adam Malik Medan, Februari - April 2013 pada 15 subjek sindroma metabolik dan 15 subjek obesitas. Hasil : Pada penelitian kami nilai rata-rata fibrinogen pada kelompok SM adalah 542.9± 209.3 mg/dl sedangkan pada kelompok obesitas 503.5±192.8 mg/dl dengan (p= 0.633), dan perbedaan ini tidak bermakna secara statistik. Tidak terdapat korelasi antara kadar fibrinogen dengan komponen sindrom metabolik Simpulan : Terdapat peningkatan kadar Fibrinogen pada kelompok sindroma metabolik dibandingkan dengan kelompok obesitas, walaupun secara statistik tidak berbeda bermakna. Tidak terdapat korelasi antara fibrinogen dengan komponen sindroma metabolik.