Kombinasi Kinin-Doksisiklin Dibandingkan dengan Kombinasi Kinin-Klindamisin sebagai Pengobatan Malaria Falsiparum pada Anak

Abstract

Results. Randomly, 246 children with positive P.falciparum malaria, separated into two groups. All sample in the two groups fulfilled inclusion criterias and completed the study. Cure rate achieved 100% from peripheral blood smear examination at day 2nd (p=0.0001). Both groups showed no recrudescence event at day 28th (p=0.000). Headache and tinnitus as adverse events were found in both group respectively. Background. There have been so much clinical trial of combination drugs for malaria treatment as alternative therapy for prevent resistency in endemic area of falciparum malaria. Some clinical trial shown that combination quinine-clindamycin and quinine-doxycycline had high eficacy for treatment of falciparum malaria in adult. But just few clinical trial that have been done with this combination treatment for children. Objective. To compare the efficacy of quinine-doxycycline combination with quinine-clindamycin combination, as the treatment for uncomplicated falciparum malaria in children. Methods. This randomized open label clinical trial was undertaken from July to August 2007 at Mandailing Natal, Sumatera Utara Province. This study was done at 8 – 18 years old children with positive Plasmodium falciparum from the peripheral blood smear. Both two group receive quinine 10 mg/KgBW orally for 4 days continued with 5 mg/KgBW for next 3 days and group I combine with clindamysin 10 mg/KgBW orally for 3 days. And group II combined with doxycycline 2 mg/kgBW/days orally once daily for 7 days. Parasitemia was counted on day 0, 2, 7 and 28. Conclusion: Both of drug combinations can be used as alternative treatments for uncomplicated P.falciparum malaria in children.