Hubungan Gambaran Bercak-Bercak Gelap (Dark Specks) pada Latar Belakang Material Nekrotik Granular Eosinofilik dengan Kadar CD4 Penderita Limfadenitis Tuberkulosis Servikalis yang Disertai HIV/AIDS

Abstract

Objective. The diagnosis of tuberculous was not difficult to establish if the spesific images found in the specimen of aspiration. However, if the image was not found in the specimen, it was difficult to distinguish between acute supuratif lymphadenitis and supuratif lymphadenitis TB, primarily for those patients with HIV/AIDS. This research was carried out to determine the relationship of dark specks image at the eosinophil granular necrotic material background with the level of CD4 to the patient cervicalis lymphadenitis TB with HIV/AIDS

Methods. This research was conducted using Exact Fisher Test with the consecutive sampling. Result. From 24 samples of patient lymphadenitis TB with HIV/AIDS was found 20 patients were male (83,3%) and 4 female patients (16.7). All of the patients were included into the productive age with the range of age from 21-49 years old. It has been found the dark specks image at 4 samples of biopsy aspiration at level of CD4 below than 200. There were the indication, the dark specks image will be appear when the immune system of patients was decrease. However, base on the result of statistical analysis, it was exhibited that there was no significant different (p>0.05) between dark specks image and CD4 level. Conclusions. There was no relationship appearance of dark specks with the level of CD4 to the patient cervicalis lymphadenitis TB with HIV/AIDS.

Latar belakang. Diagnosa limfadenitis TB mudah ditegakkan apabila gambaran-gambaran khas ditemukan pada sediaan aspirasi. Tetapi apabila gambaran ini tidak dijumpai, sulit membedakan antara limfadenitis akut supuratif atau limfadenitis TB supuratif terutama pada pasien dengan HIV/AIDS. Penelitian ini dilakukan untuk mengetahui hubungan bercak-bercak gelap (dark specks) pada latar belakang material nekrotik granular eosinofilik dengan kadar CD4 penderita limfadenitis tuberkulosis servikalis yang disertai HIV/AIDS. Metoda. Penelitian ini menggunakan Exact Fisher Test dengan pemilihan sampel secara consecutive sampling. Hasil. Dari 24 sampel penderita limfadenitis TB yang disertai HIV/AIDS dijumpai 20 orang laki-laki (83,3%) dan perempuan 4 orang (16,7%). Umur penderita seluruhnya pada usia produktif dengan rentang umur 21-49 tahun. Ditemukan gambaran dark specks pada 4 sediaan biopsi aspirasi pada kadar CD4 <200. Ada kecendrungan munculnya dark specks seiring dengan turunnya immunitas penderita, namun setelah diuji secara statistik tidak berbeda secara signifikan, dengan nilai p>0,05. Kesimpulan. Tidak ada hubungan munculnya dark specks dengan kadar CD4 penderita limfadenitis TB servikalis yang disertai HIV/AIDS.