Tampilan Pulasan Imunohistokimia Matrix Metalloproteinase-9 (MMP-9) pada Undifferentiated Carcinoma Nasofaring Tipe Regaud dan Tipe Schmincke

Abstract

Objective. Undifferentiated nasopharyngeal carcinoma have two growth pattern, they are Regaud pattern consists of well defined aggregate of neoplastic epithelial cells surrounded by fibrous tissue and inflamatory cells and Schimcke type, the neoplastic epithelial cells growth diffusely and are closely intermingled with inflammatory cells. Matrix Metalloproteinase-9 (MMP-9) is proteolytic enzyme plays significant roles in nasopharyngeal carcinoma progression, including tumor invasion and metastasis. The purpose of this research is to distinctive of matrix metalloproteinase-9 (MMP-9) expression among undifferentiated nasopharyngeal carcinoma. Methods. This research constitute analytic descriptive research with cross sectional design and Chi Square statistic analys .Sample contain of 53 nasopharyngeal biopsy, that have been diagnosed as nasopharyngeal carcinoma before. Result. There is no difference expression of matrix metalloproteinase-9 (MMP 9) on undifferentiated nasopharyngeal carcinoma Regaud type and Schmincke type. Conclusion. There were no differences in the ability of invasion on tumor growth patterns between undifferentiated carcinoma type of Regaud and Schmincke type.

Latar Belakang. Terdapat dua pola pertumbuhan dari undifferentiated carcinoma nasofaring yaitu tipe Regaud yang sel-sel neoplastiknya berkelompok dan berbatas tegas dikelilingi jaringan ikat berisi sedikit limfosit dan tipe Schmincke yang sel-sel neoplastiknya tumbuh difus dan bercampur dengan sel-sel radang. Matrix Metalloproteinase-9 (MMP-9) merupakan enzim proteolitik yang berperan dalam perkembangan karsinoma nasofaring, termasuk invasi sel tumor dan metastasis. Penelitian ini ingin melihat apakah terdapat perbedaan tampilan matrix metalloproteinase-9 (MMP-9) pada undifferentiated carcinoma nasofaring tipe Regaud dan tipe Schmincke. Metoda. Rancangan penelitian berupa penelitian deskriptif analitik dengan pendekatan secara cross sectional dan diuji statistik dengan Uji Chi Square . Sampel penelitian sebanyak 53 sampel dari biopsi nasofaring, yang sebelumnya telah didiagnosa sebagai karsinoma nasofaring. Hasil. Tidak ada perbedaan tampilan matrix metalloproteinase-9 (MMP-9) pada kedua tipe undifferentiated carcinoma nasofaring. Kesimpulan. Tidak dijumpai perbedaan kemampuan invasi pada pola pertumbuhan tumor antara undifferentiated carcinoma tipe Regaud dan tipe Schmincke.