| dc.description.abstract | Background: The active metabolite of vitamin D leads to activation of macrophage and restricts the growth of M. tuberculosis. The effect of vitamin D is achieved by binding to Vitamin D Receptor and may be influenced by polymorphisms in VDR gene.
Aim: to explore the role of FokI and BsmI polymorphisms VDR gene in susceptibility to pulmonary tuberculosis (PTB) in Indonesian Batak ethnic population.
Methods: matched case-control study with 76 PTB patients and 76 healthy normal control. Genetic polymorphisms of Vitamin D Receptor (VDR) gene were analysed using PCR-RFLP.
Results: The frequencies of FokI genotypes were FF 35.5%, Ff 55.3%, ff 9.2% for PTB patients and FF 39.5%, Ff 44.7% and ff 15.8% for normal control. The BsmI genotypes frequencies were BB 0%, Bb 68.4%, bb 31.6% for TB patients and BB 2.6%, Bb 23.7% and bb 73.7% for control. There was no significant association between FokI genotype and PTB (OR 1.39, 95% CI: 0.70 - 2.77 for Ff genotype and OR 0.65, 95% CI: 0.22 - 1.86 for ff genotype). There was a significant association between bb genotype BsmI polymorphism and PTB; bb genotype was associated with a decreased risk to PTB (OR 0.22, 95% CI: 0.11 - 0.45). After adjusting for smoking and alcohol cunsuming habit, the adjusted ORs were 0.79, 95% CI: 0.29 - 2.11 for Ff genotype and adjusted OR 0.53, 95% CI: 0.14 - 2.06 for ff genotype and OR 0.31, 95% CI: 0.13 - 0.73 for bb genotype.
Conclusions: In Indonesian Batak ethnic population, there was no association between FokI polymorphism of VDR gene with host susceptibility to PTB. For BsmI polymorphism of VDR gene, bb genotype was significant associated with a decreased risk to PTB | en_US |
