Hubungan Kadar Mean Platelet Volume dan Fibrinogen dengan Kejadian Kardiovaskular Mayor Selama Perawatan di Rumah Sakit pada Penderita Sindroma Koroner Akut di RSUP Haji Adam Malik Medan

Abstract

Introduction: Acute coronary syndrome (ACS) is a medical emergency that requires prompt hospitalization and is a major cardiovascular problem because it leads to hospital care and high mortality. Mean platelet volume (MPV) values reflecting platelet activation and fibrinogen as a protrombotic factor are expected to provide early information about the overall risk of the patient given the limited time of diagnostic efficiency of troponin heart. Objective: To determine the relationship between MPV and Fibrinogen levels against major cardiovascular events during hospitalization. Methods: Cross sectional study of patient medical record data of S ACS treated at H.Adam Malik Hospital Medan period January - September 2015. Assessed MPV and Fibrinogen at the beginning of admission. Using Chi-square statistical test. Results: 78.6% ACS patients in Adam Malik Hospital were men with the most age 51-60 years (35.7%). Most were diagnosed with STEMI (66.1%) followed by UAP (19.6%) and NSTEMI (14.3%). SKA patients who had levels of Fibrinogen (≥330) and MPV (≥9,5) as many as 24 people (42.86%) did not experience heart failure, arrhythmia, or death. From the statistical test showed no relationship between Fibronogen and MPV levels were both increased (p> 0.05). Conclusions: There is no association between MPV and Fibronogen levels with heart failure, arrhythmia or death in patients with ACS.

Pendahuluan: Sindroma koroner akut (SKA) adalah keadaan darurat medis yang membutuhkan perawatan di rumah sakit segera dan merupakan suatu masalah kardiovaskular yang utama karena menyebabkan angka perawatan rumah sakit dan angka kematian yang tinggi. Nilai mean platelet volume (MPV) yang mencerminkan aktivasi trombosit dan fibrinogen sebagai faktor protrombotik diharapkan mampu memberikan informasi dini tentang resiko menyeluruh pasien mengingat keterbatasan waktu efisiensi diagnostik troponin jantung.. Tujuan: Mengetahui hubungan antara kadar MPV dan Fibrinogen terhadap kejadian kardiovaskular mayor selama perawatan di rumah sakit. Metode: Penelitian cross sectional atas data rekam medis pasien SKA yang dirawat di RS H.Adam Malik Medan periode Januari – September 2015. Dinilai MPV dan Fibrinogen pada saat awal pasien masuk. Menggunakan uji statistik Chi-square. Hasil: 78,6 % Pasien SKA di RS Adam Malik adalah laki-laki dengan usia terbanyak 51-60 tahun (35,7 %). Sebagian besar didiagnosa STEMI (66,1%) diikuti UAP (19,6%) dan NSTEMI (14,3%). Pasien SKA yang mempunyai kadar Fibrinogen (≥330) dan MPV (≥9,5) sebanyak 24 orang (42,86 %) tidak mengalami gagal jantung, aritmia, maupun kematian. Dari uji statistik menunjukkan tidak ada hubungan kadar Fibronogen dan MPV yang keduanya meningkat (p>0,05). Kesimpulan: tidak ada hubungan kadar MPV dan Fibronogen dengan gagal jantung, aritmia maupun kematian pada pasien SKA.