Perbedaan dan Hubungan Ekspresi Vegf Antara Tumor Ovarium Ganas dan Jinak

Abstract

Objective: To describe the characteristics of patients with malignant and benign ovarian tumors, histopatological types, as well as VEGF expression differences and association between malignant ovarian tumors and benign ovarian tumors cases. Methods: Through simple random sampling 25 patients who met study criteria were obtained for each group of malignant and benign ovarian tumors. Research was done by collecting data from medical records and assessing VEGF expression of tumor cells derived from paraffin blocks on immunohistochemical examination Results : Based on ages, patients with benign or malignant ovarian tumors are most ≥40 years old, but the t test results showed significant differences on mean age between the groups (P = 0.0033). Most other characteristics are menarche age ≥10 years old, menopause and have parity ≥1. T test results showed no difference between the two groups based on menarche age, menopausal status, and parity. The most histological type was Adenocarcinoma serosum (32%). Most malignant ovarian tumors showed strong expression of VEGF (score 3-6) with mean score of 3.44±SD2,103 whereas most benign ovarian tumors showed significant differences between the two groups based on the expression of VEGF (P=0.000;95%Cl,-3.498 - -1.542). Significant association was found between strong expression of VEGF with the incidence of malignant ovarian tumors (P=0.000), which 60% of malignant ovarian tumors showed strong expression of VEGF. Conclusion: There are significant differences between groups of patients with benign and malignant ovarian tumors based on mean age, whereas no significant differences was found between the two groups based on age of menarche, menopausal status, and parity. Serosum histological type was the most frequently encountered. There are differences of VEGF expression between malignant and benign ovarian tumors. Strong expression of VEGF is associated to malignant ovarian tumor incidence.

Tujuan : Untuk mengetahui gambaran karakteristik pasien dengan tumor ovarium ganas dan jinak, jenis histopatologi, serta perbedaan dan hubungan ekspresi VEGF antara kasus-kasus tumor ovarium ganas dan jinak Metode : Melalui pemilihan secara acak sederhana diperoleh 25 pasien yang memenuhi kriteria penelitian pada masing-masing kelompok tumor ovarium ganas dan jinak. Penelitian dilakukan dengan melihat catatan rekam medis dan menilai ekspresi VEGF sel tumor dari blok parafin pada pemeriksaan imunohistokimia. Hasil : Berdasarkan usia, penderita tumor ovarium jinak maupun ganas terbanyak adalah kelompok usia ≥ 40 tahun, namun uji t menunjukkan terdapat perbedaan rerata usia yang bermakna antara kedua kelompok (P=0.033; 95% Cl, -14.161 - -0.639). Karakteristik lain yang terbanyak adalah usia menarche ≥10 tahun, sudah menopause dan memiliki paritas ≥1. Tidak terdapat perbedaan antara kedua kelompok berdasarkan usia menarche, status menopause dan paritas. Jenis histopatologi terbanyak adalah Adenocarcinoma serosum (32%). Tumor ovarium ganas paling banyak menunjukkan ekspresi kuat VEGF (skor 3-6); rata-rata skor 3,44±SD2,103 sedangkan tumor ovarium jinak kebanyakan menunjukkan ekspresi lemah (skor 0-2); rata-rata skor 0,92±SD1,222. Terdapat perbedaan bermakna antara kedua kelompok berdasarkan ekspresi VEGF (P=0.000;95%Cl,-3.498 - -1.542). Dijumpai hubungan bermakna antara ekspresi kuat VEGF dengan kejadian tumor ovarium ganas (P=0.000), dimana 60% tumor ovarium ganas menunjukkan ekspresi kuat VEGF, sedangkan hanya 8% kasus tumor ovarium jinak yang menunjukkan ekspresi kuat VEGF. Kesimpulan : Terdapat perbedaan bermakna antara kelompok penderita tumor ovarium jinak dan ganas berdasarkan rata-rata usia, sedangkan tidak dijumpai perbedaan antara kedua kelompok berdasarkan usia menarche, status menopause dan paritas. Jenis histologi serosum merupakan yang terbanyak ditemukan. Terdapat perbedaan ekspresi VEGF antara tumor ovarium ganas dan jinak. Ekspresi kuat VEGF berhubungan dengan kejadian tumor ovarium ganas.