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    Aktivitas Alkaloid dari Buah Terung Belanda (Solanum betaceum) Hasil Sambung Pucuk dengan Lancing (Solanum mauritianum) terhadap Tingkat Kehamilan Mencit (Mus musculus)

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    Date
    2011
    Author
    Harahap, Ely Suryani
    Advisor(s)
    Surbakti, Ribu
    Barus, Tonel
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    Abstract
    An investigation of the activities alcaloide from Tamarillo (Solanum betaceum) grafting with Bugweed (Solanum mauritianum) on pregnancy rate of mice (Mus musculus) was carried out. Solasodine of pea Eggplant was extracted by using chloroform and concentrated by rotary evaporator, acidified in HCl 2 N (in methanol) then NaOH 10 N was added to make pH of 9 and then fractionated with chloroform. The extract was tested on mice: the mice were divided into four groups; one control group and the other three were treated groups with three replicates (Po = Control; P1 = 5%, P2 = 10%, P3 = 15%), 1 cc /day of extract solasodine was given orally once a day for 30 days. increase in alcaloide concentration seems to leads to decrease or inhibition of pregnancy, and statistical analysis showed a very significant effect on pregnancy rates of mice with an effective concentration at 10%, concentration at which pregnancy was completely inhibited.
     
    Telah dilakukan penelitian tentang aktivitas Alkaloid buah Terung Belanda (Solanum betaceum) hasil sambung pucuk dengan Lancing (Solanum mauritianum) terhadap tingkat kehamilan Mencit (Mus musculus). Dimana solasodin dari buah Terung Belanda hasil sambung pucuk tersebut diekstraksi dengan kloroform dan dipekatkan dengan rotari evaporator lalu diasamkan dalam HCl 2N ( dalam methanol) dan dibasakan dengan NaOH 10N sampai pH 9 kemudian difraksinasi dengan kloroform. Kemudian ekstrak pekat tersebut diujikan terhadap mencit dimana mencit dikelompokkan menjadi empat; satu kelompok sebagai kontrol dan tiga kelompok perlakuan dengan tiga ulangan ( Po= Kontrol; P1=5%; P2=10%; P3=15%, dimana tiap kelompok diberikan ekstrak alkaloid 1 cc/hari secara oral selama 30 hari).Dari hasil menunjukkan semakin tinggi konsentrasi solasodin yang digunakan semakin menurunkan tingkat kehamilan pada mencit tersebut. Dan hasil statistik menunjukkan pengaruh yang sangat signifikan terhadap tingkat kehamilan mencit dengan konsentrasi efektif pada 10% dimana tidak ditemukan lagi sejumlah mencit yang mengalami kehamilan.

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    http://repositori.usu.ac.id/handle/123456789/42296
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    Repositori Institusi Universitas Sumatera Utara (RI-USU)
    Universitas Sumatera Utara | Perpustakaan | Resource Guide | Katalog Perpustakaan
    DSpace software copyright © 2002-2016  DuraSpace
    Contact Us | Send Feedback
    Theme by 
    Atmire NV