Hubungan Profil Lipid Dengan Resistensi Insulin Pada Pasien Sindroma Ovarium Polikistik

Abstract

Background: Subjects with PCOS have reproductive and metabolic disorders such as dyslipidemia, insulin resistance, and obesity Objective: To determine association between lipid profile and insulin resistance and obesity markers (BMI and WHR) in subjects with PCOS Design: This study was conducted using analytical descriptic approach with crosssectional design. Material and Method: Fifty seven PCOS-diagnosed subjects based on revised 2003 Rotterdam criteria that visited the Halim Fertility Center Clinic were obtained from May until October 2012. The subjects were interviewed and examined for their obesity markers. Venous blood samples were taken after a period of 10-12 hour fasting and were then examined for lipid profile, fasting blood glucose, fasting insulin, FSH, LH, and prolactin levels. Analysis was conducted to assess the association between lipid profile with insulin resistance and obesity markers. Results: After analyzing 57 subjects with PCOS, dyslipidemia was observed in 37 subjects (64,9%), insulin resistance in 8 subjects (14%), overweight-obesity in 24 subjects (42,1%) and central obesity in 34 subjects (59,6%). Significant association was established between dyslipidemia and insulin resistance and obesity markers (BMI and WHR) where a larger proportion of positive dyslipidemia was observed in subjects who were insulin-resistant, overweight-obese, and central obesity groups compared to subjects who were insulin-sensitive, normo-underweight, and noncentral obesity groups (p<0,05). Subject who were insulin-resistant, overweightobese, and central obesity groups were observed with a higher level of tryglicerydes and a lower level of HDL compared to subjects who were insulin-sensitive, normounderweight, and non-central obesity groups (p<0,05). Conclusion: There was significant relationship between dyslipidemia and insulin resistance and obesity markers.

Latar belakang: Penderita SOPK memiliki implikasi gangguan reproduksi dan metabolisme misalnya dislipidemia, resistensi insulin, dan obesitas. Tujuan: Untuk menilai hubungan antara profil lipid dengan kejadian resistensi insulin dan marker obesitas (BMI dan WHR) pada wanita dengan SOPK Desain: Penelitian ini bersifat deskriptif analitik dengan rancangan cross sectional study Bahan dan Cara Kerja: Didapatkan 57 pasien dengan diagnosa SOPK berdasarkan kriteria Rotterdam 2003 yang berkunjung ke Klinik Halim Fertility Center antara bulan Mei sampai Oktober 2012. Pasien diwawancarai kemudian diperiksa marker obesitasnya. Sampel darah vena setiap pasien diambil setelah dipuasakan selama 10- 12 jam untuk pemeriksaan profil lipid, gula darah puasa, insulin puasa, FSH, LH, dan prolaktin. Hubungan antara profil lipid dengan resistensi insulin dan marker obesitas kemudian dianalisa. Hasil: Dari 57 pasien SOPK didapatkan dislipidemia didapatkan 37 orang (64,9%), resistensi insulin 8 orang (14%), dan overweight dan obesitas 24 orang (42,1%) serta obesitas sentral 34 orang (59,6%). Ada hubungan yang bermakna antara dislipidemia dengan resistensi insulin dan marker obesitas (BMI dan WHR) dimana proporsi dislipidemia positif lebih besar pada kelompok resisten insulin, overweightobese dan obesitas sentral dibandingkan dengan kelompok sensitif insulin, normoweight-underweight dan WHR normal (p<0,05). Kadar trigliserida lebih besar dan kadar HDL lebih kecil pada kelompok resisten insulin, overweight-obese dan obesitas sentral dibandingkan pada kelompok sensitif insulin, normo-underweight dan non-obesitas sentral (p<0,05). Kesimpulan: Ada hubungan yang bermakna antara dislipidemia dengan resistensi insulin dan marker obesitas.