Hubungan Resistensi Insulin Menggunakan HOMA-IR dengan Rasio Profil Lipid pada Penderita Sindroma Metabolik

Abstract

Back ground :Metabolic syndrome has two fold of diabetes and five fold a head risk of cardiovascular disease in 5-10 years. The cause of metabolic syndrome is still not known for sure, but it is suspected that the pathophysiology of metabolic syndrome is associated with insulin resistancy and central obesity. Aim :To study about the association between insulin resistency and lipid profile ratio using HOMA-IR in Metabolic Syndrome Pateints. Methods : This is a cross sectional study that was conducted in inpatient and out patient RSUP. H.Adam Malik during Maret 2016 - April 2016. Patients with Metabolic Syndrome criteria IDF 2005.All samples were examined for their waist circumference, weight, height, blood pressure, Insulin, serum glucose , total cholesterol, HDL cholesterol, LDL cholesterol, Triglyserida. Result :Of the 66 sample in the study 40 (60.6%) were male and 26 (39.4%) female . In this Study , there is a significant correlation between HOMA-IR with CT/HDL ratio (r : 0.244 p <0.05); and there is a correlation between HOMA IR and TG/HDL ratio eventhough it is no significant (r : 0.120 p >0.05) and there is no correlation between HOMA-IR and LDL/HDL (p > 0.05) . Conclusion :There is a significant relationships between insulin resistency and ratio CT/HDL

LatarBelakang :Sindroma metabolik beresiko menyebabkan diabetes mellitus 5 kali lipat dan beresiko 2 kali lipat terjadinya penyakit kardiovaskular dalam 5 – 10 tahun kedepan.Penyebab sindrom metabolik masih belum diketahui pasti, namun diduga patofisologi terjadinya sindroma metabolik dihubungkan dengan resistensi insulin dan obesitas sentral. Tujuan : Untuk mengetahui hubungan resistensi insulin dan rasio profil lipid dengan menggunakan HOMA-IR pada penderita sindroma metabolik. Metode :Penelitian bersifat cross sectional dilakukan di Rawat Jalan dan Rawat Inap RSUP.H.Adam Malik Medan selama bulan Maret 2016 – April 2016. Penderita Sindroma Metabolik kriteria IDF 2005. Dilakukan pemeriksaan lingkar pinggang, berat badan, tinggi badan, tekanan darah, insulin, gula darah, total kolesterol, kolesterol HDL, kolesterol LDL, Trigliserida. Hasil : Dari 66 sampel penelitian didapatkan jenis kelamin laki –laki 40 orang (60.6%) dan perempuan 26 orang (39.4%) . Penelitian ini menunjukkan ada korelasi yang signifikan dari HOMA-IR dengan rasio KT/HDL ( r: 0.244 p <0.05) , ada korelasi antara HOMA IR dengan rasio profil TG/HDL walaupun secara statistik tidak bermakna ( r : 0.120 p >0.05) dan tidak ada korelasi antara HOMA-IR dan rasio LDL/HDL (p >0.05) Kesimpulan :Terdapat korelasi antara Resistensi Insulin (HOMA-IR) dengan Rasio KT/LDL