Perbedaan Kadar Prostacycline Cairan Darah Haid (Menstrual Fluid) pada Dismenore dan Non Dismenore

Abstract

Objective: To know the differences Of prostacycline level in menstrual fluid between a dysmenorrheal and non dysmenorrhea complaint on reproductive women. Methods: This study uses cross sectional study design by using primary data. Primary data consists of the result of menstrual blood collections on the first and second day, also questionnaires about personal identity and menstruation history. Results: Based on the study result with Anova test on the relationship between the serum level of prostacyclin and type of dysmenorrhea, the p value is <0,05, which shows relationship between serum level of prostacyclin and type of dysmenorrhea. Subjects with dysmenorrhea will have reduced serum level of prostacyclin. The study result with Anova test on the relationship between the serum level of prostacyclin and pain degree, the p value is < 0,05, which shows relationship between the serum level of prostacyclin and pain degree. The serum level of prostacyclin is directly proportional to pain degree Conclusions: There is significant relationship between the serum of prostacyclin and dysmenorrhea complaint on reproductive women.

Tujuan Penelitian: Untuk mengetahui perbedaan kadar prostasiklin cairan darah haid dengan adanya dismenore pada wanita usia subur. Desain Penelitian: Penelitian ini menggunakan desain penelitian cross sectional dengan menggunakan data primer. Data diperoleh dari hasil pengumpulan darah haid pada hari pertama dan kedua serta kuesioner berupa identitas pribadi dan riwayat haid. Hasil: Berdasarkan hasil penelitian!dengan uji Anova pada kadar prostasiklin cairan darah haid dengan jenis dismenore, diperoleh nilai p<0,05, yang menunjukkan adanya perbedaan kadar prostasiklin antara jenis dismenore dimana kelompok yang mengalami dismenore akan mengalami penurunan kadar prostasiklin. Hasil statistik dengan uji Anova yang menghubungkan kadar prostasiklin dengan derajat nyeri, diperoleh nilai p < 0,05 yang menunjukkan adanya perbedaan kadar PGI2 antara derajat nyeri dismenore, dimana kadar prostasiklin menurun selaras dengan beratnya derajat nyeri dismenore. Kesimpulan: Terdapat hubungan bermakna antara kadar prostasiklin serum dengan keluhan dismenore.