Kadar C-Reactive Protein pada Penderita PPOK Eksaserbasi

Abstract

Background. Chronic Obstructive Pulmonary Disease (COPD) is a low grade systemic inflammation disease. Local airways inflammation related with systemic inflammation burden. CRP as an acute phase protein of systemic inflammation was suggested relating with severity of COPD., Aim. Determining correlation between CRP level with severity of Exacerbation COPD. Method. A cross sectional study was conducted on 40 Exacerbation COPD patients who visit Pulmonology and Allergy-Immunology Inpatient and Outpatient Clinic H Adam Malik Hospital dan Dr Pirngadi Hospital Medan since March until June 2008. Anamnesis, physical examination, chest radiograph, spirometry and CRP serum level was measured. Statistic analysis using Spearmann’s correlation and Anova test. Result. CRP level was positively correlated with severity of Exacerbation COPD with correlation coefficent (r) 0.490 (p = 0.001). Conclusion. CRP serum level was positively correlated with severity of Exacerbation COPD.

Latar Belakang. Penyakit Paru Obstruksi Kronis (PPOK) merupakan penyakit low grade systemic inflammation. Inflamasi lokal saluran nafas berhubungan dengan beban inflamasi sistemik. CRP sebagai protein fase akut inflamasi sistemik diduga berhubungan dengan derajat keparahan PPOK. Tujuan. Untuk mengetahui kadar CRP dengan derajat keparahan PPOK Eksaserbasi. Metode. Penelitian potong lintang dilakukan terhadap 40 penderita PPOK Eksaserbasi yang rawat inap dan kontrol kepoliklinik Divisi Pulmonologi dan Alergi Imunologi RSUP H Adam Malik dan RSUD Dr Pirngadi Medan dari bulan Maret hingga Juni 2008. Dilakukan anamnesis, pemeriksaan fisik, rontgen dada, spirometri dan pemeriksaan kadar CRP serum. Penilaian dengan menggunakan Uji Korelasi Spearman dan Uji Anova. Hasil. Terdapat korelasi positif antara kadar CRP dengan derajat keparahan PPOK Eksaserbasi dengan koefisien korelasi (r) 0,490 (p=0,001). Kesimpulan Kadar CRP serum berkorelasi positif dengan derajat keparahan PPOK Eksaserbasi.