Korelasi Skor (Beck Depression Inventory) Bdi Ii dengan Kadar Vascular Endothelial Growth Factor (Vegf) pada Pasien Diabetes Melitus Tipe 2

Abstract

Depresi merupakan perasaan sedih, kecewa, putus asa, tidak ada motivasi, dan hilangnya minat dalam hidup. Depresi dinilai dengan kuosioner Beck Depression Inventory II (BDI II). Diabetes Melitus (DM) merupakan penyakit metabolik akibat defisiensi insulin atau resistensi insulin. Kejadian depresi meningkat pada penderita diabetes mellitus tipe2. Baik depresi maupun diabetes mellitus tipe 2 dapat mengakibatkan peningkatan kadar VEGF. Metode: Penelitian ini bersifat analisis korelatif dengan desain potong lintang, terhadap penderita DM Tipe 2 yang dinilai skor BDI II dan kadar VEGF- nya di poliklinik rawat jalan RSUP Haji Adam Malik Medan pada bulan November 2019. Data dialysis menggunakan uji SPPS di mana p<0,05 dianggap signifikan. Hasil: Terdapat korelasi positif sangat kuat antara skor BDI II dan kadar VEGF (p = 0,0001). Selain itu terdapat korelasi antara hemoglobin dan usia, kadar gula darah puasa dan kadar gula darah 2 jam setelah makan, kadar gula 2 jam sesudah makan HbA1C (p=0.0001, p=0,0001, p=0,0001)

Depression defined as feelings of sadness, disappointment, hopelessness, and loss of interest in life. Depression can be assessed by Beck Depression Inventory II (BDI II) questionnaire. Type 2 Diabetes mellitus (DM) is a chronic metabolic disorder due to insulin defisiency or insulin resistence. Prevalence of depression has increased two times in type 2 diabetes mellitus patients. Vascular Endothelial Growth Factor (VEGF) was a vascular permeability and angiogenesis factor. Depression and Type 2 Diabetes Mellitus would increase VEGF. Method: It was a correlative analytic cross sectional study, in November 2019 on Type 2 DM patients whose BDI II score and VEGF levels were assessed in outpatient clinic of Haji Adam Malik General Hospital Medan. Data were analyzed by SPSS. Results: There was a very strong correlation of BDI II scores and VEGF levels (p = 0.0001). Tthere was correlation between hemoglobin and age, fasting blood sugar levels and 2 hours after eating blood sugar levels, 2 hours after eating sugar levels and HbA1C (p = 0.0001, p = 0.0001, p = 0.0001) Conclusion: There was a very strong positive correlation of BDI II Scores and VEGF levels in Type 2 Diabetes Mellitus patients.