| dc.description.abstract | To analyze the correlation between levels of vitamins B12 and D with neurocognitive function in HIV/AIDS patients who are outpatients at the Pusyansus polyclinic, H. Adam Malik General Hospital Medan.
Method:
This research is an analytical study with a case series approach. The research subjects were 30 HIV/AIDS patients at the Pusyansus polyclinic, H. Adam Malik General Hospital Medan in December 2019. Subjects were selected based on inclusion and exclusion criteria. Blood samples were taken for examination of vitamin B12 and D levels. Neurocognitive function was examined by MMSE and MoCA-Ina examination. Data were analyzed using Shapiro-Wilk test statistics to evaluate the normality distribution of numerical variables, Pearson correlation test if data were normally distributed or Spearman correlation test if data were not normally distributed. A p value < 0.05 was applied to each statistical test as significant.
Results:
From the research subjects were 30 people, it was found that the majority of respondents were 17 women (56.7%), with the most education status being SMA 14 people (46.7%). The mean age of the patients was 34.8 ± 6.86 years, with the median BMI of respondents being 25.2 (20.0-40.5) kg/m2. The mean CD4 value was 515.4 ± 185.13 cells/mm3. Vitamin B12 levels had a median value of 511.5 (204.0-2640.0) ng/mL, where the majority of respondents had normal levels of 25 people (83.3%). Vitamin D levels have a mean of 21.18 ± 6.76 ng/mL, where the research subjects experienced the most insufficiency of 26 people (86.7%). Neurocognitive function has a median score for the MMSE is 28.5 (21-30), with the majority of respondents showing a normal score of 27 people (90.0%). Otherwise, the mean MoCA-Ina score was 24.17 ± 4.28, with the majority of respondents showing an abnormal score of 18 people (60.0%). The analysis showed that vitamin B12 levels were not significantly correlated with MMSE (p = 0.862; r = 0.033) or MoCA-Ina (p = 0.419; r = - 0.153). The analysis showed that vitamin D levels were not significantly correlated with the MMSE value (p = 0.757; r = - 0.059) or MoCA-Ina (p = 0.605; r = - 0.099).
Conclusion:
There was no significant correlation between vitamin B12 and D levels with neurocognitive function based on MMSE and MoCA-Ina scores (p>0.05) in HIV/AIDS patients. | en_US |
| dc.description.abstract | Untuk menganalisis korelasi antara kadar vitamin B12 dan D dengan fungsi neurokognitif pada pasien HIV/AIDS yang berobat jalan di poliklinik Pusyansus RSUP. H. Adam Malik Medan.
Metode:
Penelitian ini merupakan penelitian analitik dengan pendekatan case series. Subjek penelitian sebanyak 30 orang pasien HIV/AIDS di poliklinik Pusyansus RSUP. H. Adam Malik Medan pada bulan Desember 2019. Subjek diseleksi berdasarkan kriteria inklusi dan eksklusi. Sampel darah diambil untuk dilakukan pemeriksaan kadar vitamin B12 dan D. Fungsi neurokognitif diperiksa dengan pemeriksaan MMSE dan MoCA-Ina. Data dianalisis menggunakan statistik tes Shapiro-Wilk untuk mengevaluasi distribusi normalitas dari variabel numerik, uji korelasi Pearson jika data terdistribusi normal atau uji korelasi Spearman jika data tidak terdistribusi normal. Nilai p < 0,05 diterapkan pada setiap uji statistik sebagai signifikan.
Hasil:
Dari subjek penelitian sebanyak 30 orang, didapati mayoritas responden adalah perempuan 17 orang (56,7%), dengan status pendidikan terbanyak yaitu SMA 14 orang (46,7%). Rerata usia pasien adalah 34,8 ± 6,86 tahun, dengan median nilai IMT responden adalah 25,2 (20,0-40,5) kg/m2. Rerata nilai CD4 yaitu 515,4 ± 185,13 sel/mm3. Kadar vitamin B12 memiliki nilai median 511,5 (204,0-2640,0) ng/mL, dimana mayoritas responden memiliki kadar yang normal 25 orang (83,3%). Kadar vitamin D memiliki rerata yaitu 21,18 ± 6,76 ng/mL, dimana subjek penelitian paling banyak mengalami insufisiensi 26 orang (86,7%). Fungsi neurokognitif memiliki median skor untuk MMSE adalah 28,5 (21-30), dengan mayoritas responden menunjukkan skor yang normal 27 orang (90,0%). Sebaliknya, rerata skor MoCA-Ina adalah 24,17 ± 4,28, dengan mayoritas responden menunjukkan skor yang tidak normal 18 orang (60,0%). Analisis menunjukkan bahwa kadar vitamin B12 tidak berkorelasi secara signifikan terhadap nilai MMSE (p = 0,862; r = 0,033) ataupun MoCA-Ina (p = 0,419; r = - 0,153). Pada analisis menunjukkan bahwa kadar vitamin D tidak berkorelasi secara signifikan terhadap nilai MMSE (p = 0,757; r = - 0,059) ataupun MoCA-Ina (p = 0,605; r = - 0,099).
Kesimpulan:
Tidak ditemukan adanya korelasi yang signifikan antara kadar vitamin B12 dan D dengan fungsi neurokognitif berdasarkan skor MMSE dan MoCA-Ina (p>0,05) pada pasien HIV/AIDS. | en_US |
