Perbandingan Rocuronium Bromide 0.6 dan 1 Mg/Kg IV terhadap Mula Kerja Obat dan Kemudahan Fasilitasi Intubasi

Abstract

Background and Objectives : In general anesthesia for surgery that requires control of breathing, requires neuromuscular block drugs that is needed for intubation facilitation and anesthesia maintenance during surgery. The aim of this study is to know the drug's onset of action and intubation condition between Rocuronium Bromide 0. 6 mg/kgBW iv and Rocuronium Bromide 1 mg/kgBWiv. Methods : After getting the approval from the ethic committee of USU Medical school, 60 healthy samples were enrolled, men and women, age 17 to 60 yrs, physical state ASA I - II, who underwent elective surgery in Adam Malik General Hospital. The sample was divided randomly into two groups each with 30 subjects. All the subject received premedication with Pethidin 1 mglkgBW iv and Diazepam 0.1 mglkgBW iv 10 minutes before induction. Group A received Rocuronium Bromide 0. 6 mg/kgBW iv and group B received Rocuronium Bromide 1 mglkgBW iv. The result was measured based on the drug's onset of action with a stopwatch until maximal block was achieved measured with a TOF watch device, while the intubation condition were evaluated by using Cooper score according to the intubator who had no acknowledgement of the dosage of the drug. Results : There is a significant difference on mean of onset of action between Rocuronium Bromide 1 mglkgBWivgroup faster97.6 (SD 41.3) seconds compared to Rocuronium Bromide 0. 6 mglkgBW iv group 143. 7 (SD 62. 5) seconds, p va/ue=0.02 with Mann-Whitney U test. Mean intubation score Rocuronium Bromide 1 mg/kgBWiv group 8.9 (SD 0.18) compared to Rocuronium Bromide 0.6 mglkgBW iv group 8.2 (SD 1.3) significantly different using Mann Whitney U test with p value =0. 002. Conclusions : This study concluded that the drug's onset of action and intubation facilitation with Rocuronium Bromide 1 mglkgBW iv is faster and better compared with Rocuronium Bromide 0.6 mg/kgBW iv.