| dc.description.abstract | BACKGROUND: Genital prolapse is the features of protruding genital organs. This
disease significantly affects quality of life physically and psychologically. Etiology of
pelvic organ prolapse (POP) is multifactorial. Risk factors include age, parity, duration
of menopause, and body mass index (BMI) that induce inflammatory process in the
levator ani myopathy and neuropathy. It causes disruption of balance between Matrix
Metalloproteinase-9 (MMP-9) and Tissue Inhibitors of Matrix Metalloproteinase-1
(TIMP-1). Thus it leads to excessive degradation of extracellular matrix and resulting in
POP.
OBJECTIVE: To determine the mean serum levels of TIMP-1 between menopause
women with and without pelvic organ prolapse.
METHODS: This study is an analytical comparative study with cross sectional design
to determine difference between TIMP-1 serum level between menopause women with
and without pelvic organ prolapse. This study was conducted at H. Adam Malik
Hospital from April to July 2015. Data were analyzed with the Mann-Whitney test and
t-test.
RESULTS: This study is done to 23 menopause women with POP and 23 menopause
women without POP. Demographic data showed that, majority of subjects aged 55
years or older (54.3%), parity 3-5 (52.2%), BMI normoweight (60.9%) and have
duration of menopause 5-9 years (78.3%). Difference characteristics of the study
subjects according with age, parity, BMI, and have duration of menopause with POP
group and without POP group with Mann-Whitney test p> 0.05 which shows the
characteristics according with age, parity, BMI and have duration of menopause with
POP group and without POP group no significant difference. Mean TIMP-1 level in
POP grade 4 group is was 189.34 ± 29.98 ng/ml, lower than mean TIMP-1 level in
POP grade 3, 205.38 ± 34.43 ng/ml (p>0.05). Mean TIMP-1 level in the group with
POP is lower that the group without POP (194.91 ± 31.78 vs 219.32 ± 32.26 ng/mL;
p<0,05).
CONCLUSION: Mean TIMP-1 serum level between POP grade 3 and 4 is clinically
difference but not significant statistically. There is significant difference of TIMP-1
serum level between menopause women with and without POP. | en_US |
