Hubungan antara Kadar C-Reactive Protein dengan Derajat Keparahan pada PPOK Stabil

Abstract

Background. Chronic Obstructive Pulmonary Disease (COPD) is a low grade systemic inflammation disease. Local airways inflammation related with systemic inflammation burden. CRP as an acute phase protein of systemic inflammation was suggested relating with severity of COPD., Aim. Determining correlation between CRP level with severity ol Stable COPD Method. A cross sectional study was conducted on 40 Stable COPD patients who visit Pulmonology and Allergy-lmmunology Outpatient Clinic H Adam Malik Hospital dan Dr Pirngadi Hospital Medan since April until July 2007. Anmnesis, physical examination, chest radiograph, spirometry and CRP serum level was measured. Statistic analysis using Spearmann's correlation and Kruskal-Wallis test. Result. CRP level was positively correlated with severity of Stable COPD with correlation coefficent (r) 0.326 (p<0.005). There was no differences between mean of CRP level in each severity of Stable COPD, p = 0.209. Conclusion. CRP serum level was positively correlated with severity of Stable COPD..