Pengaruh Polimorfisme BsmI Gen Reseptor Vitamin D dan Kadar Vitamin D terhadap Kejadian Tuberkulosis Paru di Kota Medan

Abstract

Background and aims: Infection by Mycobacterium Tuberculosis is influenced by genetic and environmental factor. Vitamin D deficiency and genetic variants in vitamin D receptor (VDR) have been reported to associate with pulmonary Tubercolusis (TB). Studies investigating the interaction between vitamin D receptor gene BSMI polymorfism with pulmonary TB. Methods: We conducted a case-control study in 60 pulmonary TB patiens as a case and 60 healthy control. Vitamin D level were measured in all participant. Vitamin D receptor gene BsmI polymorfism was perfomed by PCR-RFLP. The corelation between vitamin D level and vitamin D receptor gene BsmI polymorfism with pulmonary TB were stastical analyzed. Results: The frequencies of BsmI genotypes were BB 18.3%, bb 21.6%, Bb 60% for pulmonary TB patients and BB 16.6%, bb 11.6%, Bb 71.6% for healthy control. There was no significant association between vitamin D receptor gene BsmI polymorphism and pulmonary TB (OR 0.59, 95% CI: 0.16-2.08 for BB vs bb). There was also no significant association between vitamin D receptor gene BsmI polymorphism and pulmonary TB (OR 0.45, 95% CI: 0.16-1.25 for Bb vs bb). Conclusions: There was no significant association between vitamin D receptor gene BsmI polymorphism and pulmonary TB.