| dc.description.abstract | Mandibular bone defect can be caused by several things such as trauma,
traffic accidents, post-surgery, tumor removal, and congenital abnormalities. Bone
tissue engineering involves 3 main components, namely cells, scaffold, and tissue
engineering. Mackerel bone gelatin (Rastrelliger sp.) has the ability as a scaffold in
tissue engineering, acts as a cell transport tool, provides a 3D microstructure as an
attachment site for osteoblasts to accelerate bone healing. This study aimed to
determine the effect of gelatin extract of mackerel bone (Rastrelliger sp.) on the
number of osteoblast cells on the healing of mandibular bone of wistar strain rats.
This type of research is experimental in vivo with post-test only control group
design. The sample of this study used 24 male wistar rats which were divided into
3 treatment groups, namely mackerel bone gelatin extract, positive control (FDBX
Batan), negative dick. Observation of the number of osteoblast cells was observed
on the 14th and 21st days. The results of the data obtained were analyzed using the
One Way ANOVA test which showed that there was a significant difference in the
number of osteoblasts among the mackerel bone gelatin extract group, positive
control (FDBX Batan), and negative control on days 14 and 21 with p value = 0.014.
and p= 0.032 (p<0.05). Giving mackerel bone gelatin extract, can increase the
average number of osteoblast cells in the healing of madnibular bone of wistar strain
rats. | en_US |
