Hubungan Kadar Nitric Oxide dalam Serum Pasien Dermatitis Kontak Alergi dengan Derajat Kepositifan Uji Tempel

Abstract

Background: Allergic contact dermatitis is an inflammatory skin mediated by T cells caused by repeted skin exposure to hapten in sensitized individuals- Nitric Oxide (NO) is one of the leading factors in pathogenesis of allergic contact dermatitis - Objective: To find out the correlation of NO levels in patients allergic contact dermatitis serum with the positivity degree of patching test. Methods and Subjects: The research is using analitical design cross sectional which is implemented in January 2016 - April 2016, involving 36 patients with allergic contact dermatitis to the subject of study is taken measurement of levels of NO in serum. The result of the positivity degree of patching test in accordance with the International contact Research Group (ICRD). The result were statistically analized. Results: In this study there is no significant correlation between the levels of NO to the positivity degree of patching test of nickel (II) sulfate hexahydrate (r : -

0,106, p : 0,539), potassium dichromate (r : 0,31, p=0,859), N-Isopropyl-N- phenyl-4-phenylenediamine (r : 0,093, p : 0,590), formaldehyde ( r = -0,49, p :

0,777), paraben mix (r : 0,245, p = 0, 150). Conclutions : There is no correlation of NO levels in patients allergic contact dermatitis serum with positivity degree of patching test.