Hubungan Gejala Depresi pada Penderita Penyakit Paru Obstruksi Kronis dengan Persen Prediksi FEV1 dan Indeks Bode

Abstract

Background: Data from WHO shows more than 3 million people die from COPD in 2012 and are expected to rank third after cardiovascular and cancer diseases in the future. Data in Indonesia (RISKESDAS 2013) shows the prevalence of COP D is 3. 7%. The incidence of this disease increases with age and is higher in males (4.2%) than in females (3.3%). Several recent studies have shown a high prevalence of anxiety and depression in COPD patients when compared with the control group. So it is important for clinicians to !mow the prevalence of depression in people with COPD and the negative effects it can cause. Objective: To determine the prevalence of depression in patients with stable COPD outpatients and to assess whether the symptoms of depression in COPD patients have a relationship with lung function (FEV1) and Bode index. Method: This is an observational cross sectional study of 98 stable COPD outpatients. We obtained BMI, mMRC score, CES-D score, 6MWD and FEV1 % predicted from each patient for later statistical analysis. Result: Prevalence of depression in stable COPD patients is 54.1%. COPD patients with depressive symptoms have higher mMR.C scores and FEV1 % Predicted, FVC % Predicted, and 6-min Walk Distance values are lower than those without depressive symptoms. We find a moderate strength of negative correlation (r = -0.43) between depressive symptoms (CES-D score) and lung function (FEV1 % predicted), and a strong positive correlation (r = 0.614) between depressive symptoms and BODE index. Conclusion: There is a moderate strength of negative correlation (r ~= -0.43) between depressive symptoms (CES-D score) and lung function (FEVJ % predicted), and a strong positive correlation (r = 0.614) between depressive symptoms and BODE index.