Hubungan Skor Forns dengan Derajat Fibrosis Hati yang Ditentukan dengan Fibroscan pada Penyakit Hati Kronik B dan C

Abstract

Introduction : One of the main cause of liver fibrosis is chronic infection by B and C viral. Since fibrosis is the main cause which affect morbidity and mortality in chronic liver disease, detennining grade of fibrosis is needed to give early and right treatment. Noninvasive technic, known as Ultrasound elastography or by its commercial name "FibroScan" can be more sensitive to detennine the stage of liver fibrosis and significantly in accordance with liver biopsy staging. Noninvasive examination can also be determined by Foms Score, based on 4 variables that can be obtained in common clinic include age, Gamma- glutamyl transferase (GOT), cholesterol level, and platelet count. Aim: The aim of this study were to evaluate the correlation of Foms score with liver fibrosis based on FibroScan in Chronic B and C Liver Disease. Methods: This was a cross sectional study in 43 patients with Chronic B and C Liver Disease who underwent FibroScan in Gastroenterology and hepatology division of Haji Adam Malik hospital, Medan. Serum was obtained from those 43 patients from July 2011 to Jan 2012, and analyzed for platelet, GOT, total cholesterol, and the Forns score was computed. Liver fibrosis pathology was staged according to a defined system on a scale of F0 to F4 in FibroScan. Results: From 43 subjects with chronic liver disease, 28 subjects (65.1%) were men with mean of age 47.84±12.51 years old. We found 35 subjects with Chronic B liver disease, and the other 8 subjects with chronic C liver disease. Examination of liver fibrosis staging by FibroScan, the results were F4 39.53% (17 subjects), F3 25.58% (11 subjects), F0-Fl 25.58% (11 subjects) and F2 9.3% (2 subjects) from all of the 43 patients. Assessment of liver fibrosis by Foms Score the results were; 39.53% (17 subjects) with significant fibrosis (F2-4), 37.21% (16 subjects) with mild fibrosis (Fl) and 23.26% (IO subjects) no fibrosis (F0). There was correlation of Foms score with Liver fibrosis based on FibroScan in Chronic B and C Liver Disease (p<0.05). Conclusion : There was correlation of Foms score with Liver fibrosis based on FibroScan in Chronic B and C Liver Disease. Foms score is not a reliable alternative diagnostic methode to determine the stage of liver fibrosis in chronic B and C liver disease.