| dc.description.abstract | Introduction :
One of the main cause of liver fibrosis is chronic infection by B and C viral. Since
fibrosis is the main cause which affect morbidity and mortality in chronic liver
disease, detennining grade of fibrosis is needed to give early and right treatment.
Noninvasive technic, known as Ultrasound elastography or by its commercial
name "FibroScan" can be more sensitive to detennine the stage of liver fibrosis
and significantly in accordance with liver biopsy staging. Noninvasive
examination can also be determined by Foms Score, based on 4 variables that can
be obtained in common clinic include age, Gamma- glutamyl transferase (GOT),
cholesterol level, and platelet count.
Aim:
The aim of this study were to evaluate the correlation of Foms score with liver
fibrosis based on FibroScan in Chronic B and C Liver Disease.
Methods:
This was a cross sectional study in 43 patients with Chronic B and C Liver
Disease who underwent FibroScan in Gastroenterology and hepatology division
of Haji Adam Malik hospital, Medan. Serum was obtained from those 43 patients
from July 2011 to Jan 2012, and analyzed for platelet, GOT, total cholesterol, and
the Forns score was computed. Liver fibrosis pathology was staged according to a
defined system on a scale of F0 to F4 in FibroScan.
Results:
From 43 subjects with chronic liver disease, 28 subjects (65.1%) were men with
mean of age 47.84±12.51 years old. We found 35 subjects with Chronic B liver
disease, and the other 8 subjects with chronic C liver disease. Examination of liver
fibrosis staging by FibroScan, the results were F4 39.53% (17 subjects), F3
25.58% (11 subjects), F0-Fl 25.58% (11 subjects) and F2 9.3% (2 subjects) from
all of the 43 patients. Assessment of liver fibrosis by Foms Score the results were;
39.53% (17 subjects) with significant fibrosis (F2-4), 37.21% (16 subjects) with
mild fibrosis (Fl) and 23.26% (IO subjects) no fibrosis (F0).
There was correlation of Foms score with Liver fibrosis based on FibroScan in
Chronic B and C Liver Disease (p<0.05).
Conclusion :
There was correlation of Foms score with Liver fibrosis based on
FibroScan in Chronic B and C Liver Disease. Foms score is not a reliable
alternative diagnostic methode to determine the stage of liver fibrosis in chronic B
and C liver disease. | en_US |
