| dc.description.abstract | Although hypertropic concha does not threaten our life, it disturbs quality
of life and becomes financial burden of the suferrer. Hypertropic concha is often
found in patients with allergic rhinitis and non allergic rhinitis. The pathogenesis of
hypertropic concha occurs as a result of structural changes in the air..vay tissue
called airway remodeling due to chronic inflammation. Until this time the research
on changes in vascular structure is very little, especially in the endothelium , as
well as evaluating the correlation of angiogenesis and changes in the structure of
the nasal air\vay tissues. How does the mechanism of the process of
angiogenesis in allergic rhinitis has not been clear until now.
The purpose of this study was to prove the relationship with the H 1 and
VEGF receptors expression on hypertropic concha caused by allergic rhinitis and
non allergic rhinitis, then H1 receptor and VEGF receptor as risk factors for
consideration in the management of allergic rhinitis.
This study was an observational, assess correlation H1 receptor and
VEGF receptor expression in patients caused by allergic rhinitis and non allergic
rhinitis by immunchistochemistry examination. The design cf this case-control
study , which compared to the H1 receptor and VEGF receptor in hypertropic
ccncha caused by allergic rhinitis with non allergic rhinitis. The independent
variable in this study is the H1 receptor and VEGF receptor expression, while the
dependent variable is hypertropic concha caused by allergic rhinitis and non
allergic rhinitis .
In this study, patients with hypertropic concha as many as 58 patients
consisting of hypertropic concha caused by as many as 29 patients allergic rhinitis and non allergic rhinitis is caused by as many as 29 patients. The result of
data analysis of this study showed that histamine plays a role as a risk factor for
hypertropic concha caused allergic rhinitis in which there is a significant
difference between H1 receptor positive with H1 receptor negative , with a p
value: <0.0001 ( p < 0.05 ), OR: 30 and 95 % Cl:5,833-154,29. Based on this
study found signifficantly VEGF receptor between in hypertrophic concha caused
by allergic rhinitis and in hypertrophic concha caused by non allergic rhinitis which
p value:0,022. Receptor VEGF is not risk factor for the occurrence of hypertropic
concha caused by allergic rhinitis, which OR: 0.11 and 95 % Cl:0,013-0,982, so
that receptor VEGF is protectif factor. In this study found that correlation between
histamine 1 receptor and VEGF receptor 1 in the hypertropic concha caused by
allergic rhinitis is possitive but weakness, which Sppearman's rho statistic test
found correlation coeficient:0,278 and p value:0, 144 | en_US |
