Efektivitas Sinbiotik pada Anak Dermatitis Atopik

Abstract

Background. Atopic dermatitis (AD) is a chronic itchy inflammatory disease of the skin. The role of synbiotic in treatment of the atopic dermatitis has shown varying results. Objective. To determine the effectiveness of synbiotic in AD treatment. Methods. A randomized controlled triat was conducted from July until August 2015 at primary health centres in Medan. Fifty two children with AD was included in the study. Subjects were divided into two groups, 26 children in each group. Group A received synbiotic and emolient, Group B received placebo (maltodextrin) and emolient. Both groups were followed for 14 days and SCORAD (Scoring of Atopic Dermatitis) index was assesed to determine AD severity in day 0, 7, 10, and 14. Data was analysed using Mann Whitney test. Results. Mean SCORAD index reduction from day O until 14 of group A was better than group B, implying that synbiotic has a role in AD treatment. But unfortunately this result was not statistically significant (P > 0.05). The EER and CER in this study was 80.77% and 73.08% respectively, NNT score of synbiotic treatment was 13.00. Conclusions. Synbiotic was associated with better SCORAD index reduction in 14 days than placebo, but this was not statistically significant. Synbiotic is not effective in treatment of AD in children.