Perbandingan Efek Analgesi dan Efek Samping Oxycodone dan Morphine Intravena sebagai Analgesi Preemptive pada Pasien Bedah Elektif di RSUP H. Adam Malik

Abstract

Introduction: Pain is an unpleasant feeling and emotional experience associated with tissue damage. Intraoperative and postoperative pain cause discomfort, decreased satisfaction, and delayed cure, and may increase health costs. This study aimed to investigate the comparison of efficacy between oxycodone and morphine as preemptive analgesia and to compare postoperative nausea and vomiting (PONV) side effect in postoperative patients at Haji Adam Malik General Hospital, Medan-Indonesia. Method: The study design using a double-blind, randomized controlled trial to investigate the effectiveness of oxycodone with an initial bolus of 5 mg and followed by maintenance dose 0.02 mg I kg body weight and continuous intravenous morphine with an initial 4 mg bolus followed by maintenance dose 0.05 mg / kg body weight as an preemptive analgesia in patients undergoing long bones operation under general anesthesia. The visual analog scale (VAS) assessment and side effects were performed directly by the researchers at 0 (TO), I (Tl), 2 (T2), 3 (T3), 6(T6), 12 (Tl2), and 24 (T24) hours after surgery ends. Side effects of nausea and vomiting were assessed using PONV scores (postoperative nausea and vomiting) and measured together with VAS. Data analysis used independent sample t-test to compare VAS and PONV score between oxycodone and morphine group Results: Subject characteristics There were differences in VAS at time measurements TO and T2. Comparison of PONV scores between the oxycodone group and morphine group was not found to be different across all assessment times (p> 0.05). Conclusion: There was no difference in analgesia effect between oxycodone and morphine, there was no significant difference in PONV score between oxycodone and morphine