Gambaran Hasil Pengobatan Panduan Jangka Pendek pada Pasien TB Resisten Obat di RSUP H. Adam Malik Medan

Abstract

Background: Based on WHO Global Report 2020, Indonesia placed 2nd in the world as country with high burden case of tuberculosis with estimated case 562.049 in 2019. In 2018, shorter-term regimen (STR) was introduced as new regimen for treating MDR-TB Patient. The aim of this study is to determine treatment result of shorter-term regimen for MDR-TB treatment. Methods: This is a descriptive study, subject were patients admitted at Adam Malik General Hospital with confirmed multidrug resistant TB (MDR-TB) between January 2017-December 2019. Data retrieved from medical record with a time span of Mei-September 2021. Inclusion criteria included age > 20 years, not pregnant, confirmed multidrug resistant TB based on Gen-xpert and MGIT test, and not extrapulmonal TB. Exclusion criteria included Pre-XDR-TB or XDR-TB patient, history of MDR-TB treatment > 1 month and history of failure to treat MDR-TB. Results: Of 202 patient, 152 patient were matched inclusion and exclusion criteria. The majorities were male (70.4%) and female (29.6%). The > 60 year age group is 11,2% and < 60 years age group is 88.8%. 63 subject (41,5%) has comorbids. 52 subject with comorbid of DM (34,2%), followed by CHF in 5 subject (3,2%), HIV 3 subject (2,0%), 1 subject (0,7%) with DM and HIV, and 1 subject (0,7%) with DM and CAD. Distribution of treatment outcome with 72 subject (47,4%) cured, 53 subject (34,8%) default, failure 10 subject (6,6%), 17 subject (11,2%) died. Correlation between age and treatment result was found with p = 0,038 (p<0,05) which there is a relation between age and treatment result. Next, the correlation between gender and treatment result with result p = 0,152 (p>0,05) which there is no relation between this variable. Last, correlation between comorbids and treatment result with p = 0,497 (p>0,05), which showen no relation between this variable. Conclusions: from this study, 72 subject (47,4%) cured. There is a correlation between age and treatment outcome with p = 0,038 (p<0,05), there is no correlation between comorbids and treatment outcome and gender with treatment outcome