Pengaruh Pemberian Vitamin E terhadap Jumlah dan Hitung Jenis Leukosit pada Mencit Betina Dewasa (Mus Musculus L) yang Mendapat Latihan Fisik Maksimal

Abstract

This research is intended to know the effect of tocopherol administration to the leukocyte count and differential counts at.female adultmouse (Mus musculus L.) which made to obtain maximum physical exercise. This research used 25 mice which divided into one control group and four treatment groups. The first group (PO) as the control group did not obtain any treatment The second group (Pl} obtained only maximum physical exercise everyday in 28 days, the thitd group (P2) obtained maximum physical exercise and 0,5 ml/day per oral aquadest in 28 days, the fourth group (P3) obtained only maximum physical exercise everyday in the first 14 days, and obtained maximum physical exercise and 2 mglday per oral tocopherol in addition for the next 14 day~ the last fifth group (P4) obtained maximum physical exercise and 2 mg/day per oral tocopherol in 28 days. The result showed that tocopberol administration did not influence the average of leukocyte count · and differential counts and the average of basopbils, eosinophils, limphocytes · and monocytes count and amount of female mature mice (Mus mU$culus L.) which obtained maximum physical exercise (P>0,005); but the tocopherol administration influence the average of neutrophils count and amount of female mature mice (Mus musculus L.} which obtained maximum physical exercise (P<0,005). Maximum physical exercise did not lead the occurrence of oxidative stress which affected the leukocyte count and differential count tocopherol as antioxidant could depress the neutrophils count with 2 mg/day per oral dose in 14 days.