| dc.description.abstract | Background: Monosodium glutamate (MSG), a food additive that is still a
controversial, where some states are safe, but partly it's harmful to health. Honey
has been received by the public, as a drug. Giving honey in pregnant mice after
giving MSG, will reduce the negative impact of MSG.
Objective: The purpose of study was to determine the effects of honey therapy
against fetal development disorder of mice and hepatic lesions induced by giving
of high doses of MSG during pregnancy
Methods: The study is purely experimental with a Completely Randomized
Design (CRD), which consists of five groups, there are one control group and four
treatment groups. The control group was given distilled water only during
gestation days 0-18. The first treatment were given MSG 4mg/g body weight/day,
the second treatment were given honey 0,15g/20g body weight /day, and the
fourth treatment were given MSG 0.15 g/20g body weight/day and honey 4mg/g
body weight/day, as long as 0-18 days of gestation. The third treatment groups
were given MSG 4mg/g body weight/day on days 0-7 of pregnancy, and
continued provision of honey 0,15g/20g body weight/day on days 8-18 of
pregnancy. At gestational age 18 days, each treatment and control mice were
killed by cervical dislocation and then dissected for liver and fetuses removal
Result: Giving of high doses of MSG to mice during pregnancy, give embriotoxic
effect, characterized by decreased the number of live fetuses up to 54,9%
(p=0,003) and increased the number of embrio resorption up to 58,86% (p=0,02),
and hepatotoxic effect compare control with p value = 0,041. Giving honey can
reduce hepatotoxic and embriotoxic of MSG effect, particularly they are giving
together will increase the number of live fetuses up to 100% and decrease the
number of embrio resorption up to 0%. | en_US |
