Hubungan Ekspresi Fibroblast Activation Protein (FAP) terhadap Rekurensi Kanker Ovarium Epitel

Abstract

Background: Epithelial ovarian cancer is the most lethal gynecological cancer and 80% of patients diagnosed at advanced stage which related to high recurrence rate. Currently, FAP expression has been thought to be a significant biomarker to predict recurrence rate of epithelial ovarian cancer. Objective: This study aimed to determine the correlation between fibroblast activation protein (FAP) expression and epithelial ovarian cancer recurrence. Methods: This is an analytical observational study with case control design. The sample was 40 paraffin block consist of 20 epithelial ovarian cancer samples with recurrence in 1 year after treatment and 20 samples without recurrence. All samples were immunostained with FAP antibody and FAP expressions were interpreted by two anatomical pathologists using Allred score. The correlation between variables was analyzed by chi square statistical test with 95% confidence interval and p< 0.05 was considered significant. Results: There was a significant correlation between FAP expression and histopathological type of ovarian cancer (p=0.042). A significant correlation was found between FAP expression and ovarian cancer stage (p=0.030). There is a significant correlation between FAP expression and histopathological grading (p=0,01). There is statistically significant correlation between FAP expression and ovarian cancer recurrence (p=0.004). with OR 7.429 (95% CI: 1.778-31.040), which means that higher FAP expression increases ovarian cancer recurrence risk 7.429 times greater than lower FAP expression. Conclusion: Elevated FAP expression in ovarian cancer can be used to evaluate recurrence and cancer cell progression.