| dc.description.abstract | Background: Leptin is the adipokines, which is considered to have a role
in obesity and related metabolic dysfunction. Leptin rcsistance is likely to
undedie the cognitive dysfunction associated with diabetes mellitus.
Objective: This study aimed to determine the conelation of plasma leptin
levels and cognitive function in patients with and without diabetes mellitus.
Methods: This study was a cross sectional study, with subTbcts DM and
non DM patients who were matched. Subjecfs examined cognitive function
by MMSE and CDT, then the patient fasted 1G12 hours to be examined
plasma leptin levels.
Resul6.' From the 80 samples of patients with and without DM were
gained 42 women (62.5/o) and 38 men (47.5o/o) with a mean age of 51.85 t 8.47. ln patients with DM and without DM were the largest tribe of the
Batak of 25 people (62.5yo) and 29 (72.5o/o) respectively. The mean
MMSE in DM patients was 24.03 x 2.91 and 28.68 t 1.59 in patients
without DM. There are significant differcnces between the MMSE scoing
average of DM patients with patients without DM. (p <0.05). The mean
plasma leptin levels in patients with DM was 16887.45 *, 15171.11 and
21447.11 t 15154.38 in patients without DM. The mean BMI was 24.96 t
3.67 in patients with DM aN 26.25x 4.00 in patients without DM. The
mean MMSE in both DM contrcl, moderate and bad consisfs of 24.64 t
2.91, 25.75 *, 4.35 and 23.48 x 2.63, respectively. Therc were no
significant differences between DM conhol good, moderate and poor (p =
0.338) There was no significant correlation between leptin levels and
cognitive function in patients with and without DM with r = 0.084, p = 0.608
and r= 0.127, p = 0.436, rcspectively.
Gonclusion: The rcsults of this study indicate that therc is no significant
conelation between leptrn leve/s and cognitive function in patients with DM
and non DM | en_US |
