Perbandingan Efek Induksi Propofol dengan Ketamin terhadap Penurunan Nilai Neutrofil pada Pasien dengan Tindakan Anestesi Umum

Abstract

Background : Leukocyte are part of innate immunity (congenital). Decrease in the value ofneutrophils can be used as a simple parameter to measure the severity of stress and systemic inflammation in patients with critical condition. Some research suggests the influence ofanesthetic drugs on leukocytes and other studies that look at the effect of anesthetic drugs on function of leukocyte subsets especially neutrophils. This research was conducted to find out tlte difference of induction effect of propofol and ketamine on decrease in the value of neutophils in patients under general anestbesia. Methods : Research clinical trials with Double Blind Randomized Control Trial conducted in 32 patients ASA I and II were devided into two groups who underwent general anesthesia. Patients in group propofol (A) given 2mglkg propofol. patient in group ketamine (B) given 2mglkg ketamine. Then the measured value of neutrophils before induction (Tl), lO minutes afler intubation (T2), and 60 minutes after intubation (T3)- Result : By using the TJndependent and Mann-Whitney U Test we formd T1

Neutrophils p-value : 0,636, T2 Neutrophils p-value : 0,846, T3 Neutrophils p- value = 0,403.

Conclusion ; There was a difference in induction effect between Propofol and ketamine on decrease in the value of neutrophils. There is statistically sipificant effect of ketamine on difference in the value of neutophils, and there is no statistically significant effect of propofol on difference in the value of neutrophils.