Perbandingan Efektifitas dan Efek Samping Pemberian Ketamin Dosis 0,25 Mg/KGBB Intravena dan Meperidin Dosis 0,4 Mg/KGBB Intrayena untuk Penanganan Menggigil Paska Operasi dengan Anestesi Umum

Abstract

Background: Shivering have adverse physiological effects and one common complication after general anesthesia. The inoidence of shivering after general anesthesia is approximately 40-60%. Overooming shivering becomes very important. Meperidine drugs are widely used in different hospitals.Meperidine have unweloome side effects, Ketamine is another alternative to overcome chills. Given the procedures and the availability of ketamr-ne periphetal hospital easier. Has been much research done, but I am anxious to investigate the effectiveness and side effects of ketamine administration and meperidine as a therapy in the treatment of shivering after general anesthesia. Methods: The study used a double-blind randomized clinical fial on 60patients. Patients were divided into two !troups A (ketamine 0.25 milligrarns / kg / iv) and B (meperidine 0,4mg / kg / iv) / iv. Shivering was assessed using BSAS score 5 points (0ll/2/3/4), when BSAS score> 1 is given the appropriate therapy Envelopes received, said to be effective when BSAS score to 0. The side effects of nausea and vomiting was assessed by a numerical scale 4 point ( 0lll2/3). The data were anabrzed using independent T-test, Marm-Whitney test, Chi-square test, Kolmogorov-Smirnov trvo sample test and Fisher's Exact with a significance level of 95o/o and p <0.05 was oonsidered statistically significant. Results: In goup A was found 29 patients (93%) BSAS be 0, in pgoup B 20 patients (70%), group A is more effective for the treatment of shivering after general anesthesra, although not statistically significant fpr, 0.05). The side effects of nausea and vomiting A group of 6 patients (6 7,A, goup B 12 patients $0%) (p <0.05). Respiratory depression is not found grouped A. Conclusion: administration of ketamine dose 0.25 mg lkg liv more effective than meperidine dose 0-4 mg / kg / iv for the treatrnent of post-genera"l anesthetic shivering, nausea, vomiting less in the ketamine group, and there is no respiratory depression.