| dc.description.abstract | Research has been carried out on the utilization of flavonoid compounds from papaya
leaf extract as a tyrosinase inhibitor in the process of skin pigmentation. This study
aims to determine the effect of papaya leaf extract on the area of vitiligo, percent
repigmentation and the amount of melanin pigment after monobenzone was applied.
This research was completed from February to June 2022. The research design used
in this study was a Completely Randomized Design (CRD) consisting of 5 treatment
groups, namely K- (administration of monobenzone), K+ (administration of
monobenzone and commercial ointment), P1 (administration of monobenzone and
ointment of papaya leaf extract 25%), P2 (administration of monobenzone and
ointment of papaya leaf extract 50%) and P3 (administration of monobenzone and
ointment of papaya leaf extract 75%). The results showed that papaya leaf extract with
a concentration of 75% was the best in reducing vitiligo area, increasing the
percentage of pigmentation and increasing the amount of melanin pigment with a
vitiligo area of 0.102 cm2, repigmentation percentage of 73.74%, and the amount of
melanin pigment as much as 454.04 pigments. characterized by darkening of the skin
of mice | en_US |
