Faktor Risiko Infeksi Jamur Sistemik pada Bayi Berat Lahir Rendah yang Mendapat Sefalosporin Generasi Ketiga

Abstract

Background Fungal infection may cause late-onset sepsis in low birth weight infants. lnvasive fungal infection (lFl) is a cause of morbidity and mortality in neonates. A number of potential factors for the development of lFl have been identified including low birth weight, gestational age <32

weeks, vaginal delivery, use of broad spectrum antibiotics such as third- generation cephalosporin and carbamapenem, cenfal venous catheters,

mechanical ventilation, parenteral nutrition, intralipid, abdominal surgery, necrotizing enterocolitis, prolonged hospitalized, and thrombocytopenia. Objective To determine risk factors of invasive fungal infection in low birth weight exposure to third-generation cephalosporin Methods A cross sectional study has been done on October 2011 to April 2012 with participants 82 low birth weight infant < 2500 g with suspected sepsis and exposure to antibiotics third-generation cephalosporin :5 days. lFl was diagnosed on positive fungal culture from blood. Statistical analyses used was Fisher exact test and multivariate logistic regression to assess risk factor$ of lFl Results Of 82 low birth weight infunts included subjects, 9 infants (10,9%) were proved to have lFl. Candida albicans was the most fungal species causing lFl. There was a significant association between parenteral nutrition and intralipid with lFl (P < 0.05). Lipid use was risk factor lFl (OR = 9.95; Cl 957o = 1.90 - 52.16, P=0.007) by multivariate analysis Conclusions The use of lipid retained significance as an independent risk factor of invasive fungal infection.