| dc.description.abstract | HIA gene is suspected to be have a role in the development of
nasopharyngeal carcinoma (NPC). To assess the relation between HLA-
DRBl dan HLA-DQB1 alleles with NPC among the Batak people, this case-
control study was performed using samples consisted of 55 case and 104
controls. DNA isolation was conducted at the Laboratorium Terpadu of
Universitas Sumatera Utara, while gene allele identification was carried out
using PCR-SSO reverse dot blot method at The Department of
lmmunohematology and Blood Transfusion, Leiden University Medical
Center. The majority of NPC sufferers were males (60%), 50-59 years old
(29,090%), and work as farmer (36.363%). Histopathologically, the majority
was WHO Type 3 (54.545%), followed byWHO Type 1 (29.091%) and WHO
Type 2 (16.364%). Most of them were in Stage lll (67.273%), followed by
Stage lV (25.455o/o) and Stage ll (7.273o/o). There was a significant
relationship between daity consumption of satted fish before the age of 10
years old with NPC (p<0.05), OR 6.029 (Cl 2.900-12.538). The shortest
genetic distance was found between the Batak people with the Kalha
Mongolia tribe (D=0.291), compared to the population of Man of North China
and South Koreans. Highest frequency of allele gene of Batak population
etnic was HLA-DRB1.12 (71.154Yo) and HI-A-DQB1"0301 (75.962%), and
among the NPC sufferers it was H1A-DR81.12 (63.363%) and HLA-
DQB1.0301 (70.909%). HLA-DRB1.08 allele gene was significantly
associated with NPC (p<0.05), OR 4,122 (Cl. 0.989 - 17.180). This study concludes that HIA-DRB1.08 allele gene has a potential in the susceptibility
for NPC among the Batak people | en_US |
