| dc.description.abstract | Background. Health Department of Indonesia Republic had changed the
standard treatment of falciparum malaria into artesunate-amodiaquine
combination since end of 2004. This was caused by previous malaria drugs
have been resistant. We need to find alternative drug if this combination drug
is not available.
Objective. To compare the efficacy of artesunate monotherapy with quinine-
azithromycin combination, as the treatment for uncomplicated falciparum
malaria in children.
Methods. This randomized open label clinical trial was conducted on July to
August 2007 at Mandailing Natal, Sumatera Utara Province, in 5 to 18 years
old children with positive P. falciparum from the peripheral blood smear.
Group I received artesunate monotherapy orally and group II received
quinine combined with azithromycin orally. Parasitemia was counted on day
0, 2, 7 and 28.
Results. The cure rate was 100% and no recrudescence for both group on
day 2, 7 and 28 (P=0,001). Headache, vomiting and tinnitus adverse event
was found in 14, 7 and 4 children in group II (P=0,0001; 0,027; 0,039 )
respectively.
Conclusion. Both of drugs can be used as alternative treatment for
uncomplicated falciparum malaria in children, but combination of quinine-
azithromycin have more serious adverse reactions than artesunate
monotherapy | en_US |
