| dc.description.abstract | Backgroud: Differentiating exudative and transudative pleural effusion is
essential for further appropriate workup and treatment. Many studies have
evaluated pleural fluid lactate dehydrogenase (pLDH), protein (pProt) and
cholesterol (pChol) for that purpose. Previously however, there is no study has
shown the strength of diagnostic combination from those three parameters
Objective: To evaluate the benefit of three pleural fluid parameters pLDH, pProt
and pChol both in single or combination form for differentiating exudative and
transudative pleural effusion.
Methods: Sixty six cases of pleural effusion at Adam Malik Central Hospital
from January-Mei 2014 were divided into exudate (56) and transudate group (10)
based on their definite clinical diagnosis. Furthermore, comparations were made
between all parameters in single and combination form to evaluate the strength
between those criteria in order to differentiate between exudate and transudate
pleural fluid.
Results: All parameters both in single or combination form were statistically
different (p < 0,05) between exudate and transudate. However, the combination of
two or more from three parameters (pLDH+pProt I pLDH+pChol / pProt+pChol /
pLDH+pProt+pChol) were found superior in accuracy (92,4%), sensitivity
(94,6%), and NPV (75%) compare to others.
Conclusion: This study found that combination of two or more from three
parameters (pLDH, pProt and pChol) has superiority in differentiating exudate
and transudate pleural fluid | en_US |
