Pengaruh Ekstrak Etanol Buah Buncis (Phaseolus vulgaris L.) terhadap Aktivitas Superoksida Dismutase dan Histopatologi Pankreas Tikus Wistar (Rattus norvegicus) Hiperglikemia

Abstract

Background : Alloxan tetratrydrate generates free radicals and highet reactive oxidative species production (SOR), which can lead to reduced insulin secretion

from pancreatic p cells and decreased insulin receptor sensitivity in insulin- receptor cells resulting in hyperglycemia conditions. Ethanol Exfact Bean Fruit

can reduce oxidative stress. The purpose of this study was to determine the effect of ethanol extract of beans on the decrease of blood sugar level, increase of superoxide dismutase enzyme activity and histopathology of allokan-induced altered wistar pancreas. Method : This research is an exprimental research. The posttest only control group design ffidy, using rat (Rattus norvegicus) strains of wistar, w{ls randomized in five groups: negative control, psitive conftol, ethanol extract of 200rng / kgbb, 400mg / kgbb, 600mg / kgbb. Results : This study showed a significant reduction in blood sugar levels when compared with the control group. Superoxide dismutase enzyme activity increased but was not statistically signifrcant. Observation of pancreatic histopathology showed a change in diarneter in the group receiving ethanol extract of beans. Conclusion : From the result of this study there was no significant difference to the decrease in blood cadital blood of male wistar ruts (Rattus Norvegicas) when compared with positive controls but statisticallly decreased blood sugar levels of male wistar ruts (Rattus Norvegicus) there was a significant difference