Perbedaan Kadar SGOT dan SGPT pada Pasien TB Paru dengan Pemberian Obat Antituberkulosis di RSUD Dr. Pirngadi Kota Medan

Abstract

Background. Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis. Tuberculosis mainly affects the lungs, making lung disease the most common presentation. TB treatment is given in the packaged form of Fixed Dose Combination Antituberculosis Drugs (OAT-KDT) in general, namely rifampicin, isoniazid, ethambutol, and pyrazinamide. Side effects The OAT-KDT most often found include digestive disorders, visual disturbances, and impaired liver and kidney function. Aim. The purpose of this study was to determine the differences in SGOT and SGPT levels in Pulmonary TB patients who were given antituberculosis drugs. Methods. The data used in this study were retrospective, namely secondary data and data collection tools in the form of medical records. Results. There was no significant difference in point scores between the control and treatment. Some levels of SGOT and SGPT are still expected. Normal or decreased levels of SGOT and SGPT may be due to pharmacokinetic tolerance events. Pharmacokinetic tolerance is a change in drug distribution or metabolism after repeated administration so that it does not burden the liver. Conclusion. There is an effect of the frequency distribution of sex, the average levels of SGOT and SGPT in Pulmonary TB patients who are given antituberculosis drugs, the influence of the frequency distribution of antituberculosis drugs used in tuberculosis patients in RSUD Dr. Pirngadi City of Medan but not significant, and there is an effect of the age frequency distribution with SGPT from tuberculosis patients who were given antituberculosis drugs at RSUD Dr. Pirngadi Kota Medan.