Hubungan antara Ekspresi Neuregulin 1 dengan Karakteristik Penderita Astrositoma Intrakranial di RSUP Haji Adam Malik Medan Tahun 2016-2018

Abstract

Introduction: Astrocytoma is the most common primary brain tumor. A complex interplay among adhesion molecules, proteases and cytokines that regulate their expression likely underlies tumor progression. Neuregulin 1 (NRG1) is a cytokine that play role in progression and invasion of tumor cells by activating signal after binding its receptor. Neuregulin 1 expression is considered as one of astrocytoma prognostic parameter. Objective: The objective of this study is to analyses relationship between NRG1 Expression with characteristic of intracranial astrocytoma. Method: This study is retrospective study using analytic method. This study measures NRG1 expression, then analysing the association between NRG1 expression in astrocytoma patients. The study held at Haji Adam Malik Hospital Medan from September 2016 to August 2018 with total samples are 32. Results: From this study, there is no significant association between NRG1 expression with age (p=0,853) and gender (p=0,565) of astrocytoma patients, otherwise there is a significant association between NRG1 expression with cell proliferation (p=0,00), WHO grading of astrocytoma (p=0,00) and outcomes (p=0,023). In this study, the most common result are strong NRG1 expression has many cell proliferation in 10 (31,1%) patients, strong NRG1 expression with grade IV astrocytoma found in 7 (21,9%) patients and moderate NRG1 expression in live patient found in 7 (21,9%) patient. Conclusion: In this study, there is significant association between NRG1 expression and cell proliferation, WHO grading of astrocytoma and outcomes.