Hubungan Kadar Vitamin D Serum dengan Resistensi Insulin yang dinilai dengan Kadar Homeostatic Model Assessment Insuline Resistance (Homa - Ir) pada Wanita Menopause

Abstract

Background: Hormonal imbalance in post-menopausal women, causing changes in glucose metabolism. This can reduce the quality of life for postmenopausal women and increase the risk of Diabetes Mellitus and other systemic diseases. There is literature that states that Vitamin D deficiency can adversely affect insulin resistance. A decrease in estrogen levels in the blood is also thought to result in a decrease in the production of Vitamin D and its receptors. Methods: This research is an observational analytic study with a cross-sectional study design. To assess the relationship between serum Vitamin D levels and the risk of insulin resistance in postmenopausal women assessed using HOMA-IR. Research begins in November 2022 until the number of samples is fulfilled. The research was conducted at CPL Hospital, Universitas Sumatera Utara. This research was conducted starting from the approval of ethical clearance from the ethical committee. Results: Research was conducted on 34 menopausal women as research samples. Characteristic data were taken using a questionnaire. Examination of Vitamin D, Fasting Insulin Levels, Fasting Serum KGD and HOMA-IR calculations were carried out. The mean age of menopausal women who were the sample of this study was 54.44 years with a standard deviation of 2.90. The mean length of menopause in this study was 5.29 years with a standard deviation of 2.09. The average fasting serum insulin level in this study was 28.04 IU/mL with a Standard Deviation of 15.47 ng/mL. The average fasting serum blood glucose level in this study was 102.88 with a standard deviation of 17.05 mg/dL. The mean vitamin-D level in this study was 24.33 ng/mL with a standard deviation of 7.89 ng/mL. The mean HOMAIR level in this study was 7.23 with a standard deviation of 4.21 mg/dL. Conclusion: This study concluded that there was an inverse relationship between Vitamin D and HOMA – IR levels in Menopausal Women, meaning that an increase in Vitamin D levels would decrease.