Hubungan Prognostic Nutritional Index dengan Kejadian Infeksi Luka Operasi pada Pasien Bedah Onkologi-Ginekologi

Abstract

Background: Albumin and lymphocytes are important components that reflect the nutritional and immunity status. Prognostic nutritional index markers calculated with albumin and lymphocyte count are considered to be predictors of surgical site infection in patients undergoing gynecological cancer surgery. Objective: To assess the relationship between the prognostic nutritional index and the incidence of surgical site infections in oncological-gynecological surgery patients Methods: This study was an observational analytic study with a retrospective cohort design conducted at Adam Malik Haji Center General Hospital, Medan. This research started in October-December 2022. There were 84 patients during the study. An analytical test was performed with Fisher's exact test. Results: The majority of patients undergoing gynecological cancer surgery were aged <50 years (52.4%), senior high school (46.4%), housewives (71.4%), and multiparas (71.4%). Based on clinical and laboratory results, the majority were normoweight (61.9%), with ovarian cancer (79.8%), high-grade serous carcinoma (26.2%), stage III (42.9%), had no history of NAC (90.5%), underwent optimal debulking laparotomy ( 86.9%), mean length of operation ≥ 3 hours (61.9%), average length of stay ≥ 4 days, (59.9%) mean PNI value of 56.62, albumin normal (59.5%), abnormal (40.5%), and for total lymphocytes normal (56% ), abnormal (44%). Superficial SSI incisions were found in 33.3% of patients, and deep ILO incisions were found in 1.2% of patients. The results of statistical analysis showed that there was no relationship between PNI and surgical wound infection (p > 0.05). Conclusion: The results of this study from the results of a direct analysis, PNI and the SSI did not have a significant relationship. Therefore, PNI cannot be used as a predictor of SS in patients undergoing gynecological cancer surgery.