| dc.description.abstract | Hypercholesterolemia can causes the abnormalities of the male
reproductive function , achieved increase of oxygen radicals and lipid
peroxidation production in different tissue, and inducing oxidative stress. The
results is damage sperm membranes, structure of proteins and DNA that effect on
fertility. Vitamin C is the major chain breaking antioxidant and can neutralize
free radical.
This study is an experimental design using 35 rats aged 8-12 weeks with
body weight 150-200 gram were devided into 5 groups, PO = Rats that received
standard food as control on days 1-60, P 1 =Rats that received fatty food on day 1-
60 =, P2= =Rats that received fatty food +vitamin Con days 1-60, P3 ==Rats
that received fatty food on day 1-30, a standart food for 31-60 days, P4= Rats
that received fatty food on days 1-30, vitamin Con day 31-60 (vit C= 3, 6 mg/ day,
yolk= 5graml 200 gr bodyweight). Total cholesterol levels checked before and
after treatment on day 1 and day 61. Then observed seminiferous tubules
epithelium thickness and quality and quantity of sperm cell after the rats
decapitated. Univariate analysis to calculate the mean and standard deviation.
Test data with the Shapiro Wilk normality, followed by One Way Anova, Post
Hoc, Kruskal Wallis and Mann Whitney Uwith SPSS 18.0for windows.
Total cholesterol levels before and after treatment were not significantly
different (p>0,05), seminiferous tubules epithelium thickness was significantly
different in each group (p<0,05). The quality and quantity of sperm cells in each
group was significantly different (p<0, 05). Giving vitamin C can improve and
maintain the semin~ferous tubules epithelium, the quality and quantity of sperm
cells hipercolesterolemia rats but had no effect on total cholesterol levels | en_US |
