| dc.description.abstract | Background: Dyslipidemia is marked by an increase of total cholesterol, low
densiry lipoprotein cholesterol (LDL) dan trygl;serida (TG), and a decrease of
high density lipoprotein cholesterol GfDL) A few study conclude that pancreatic
B cell dysfunction due to dyslipidemia could lead to diabetes mellitus (DM) type 2
and a constitute of DM type independen risk factor. This shrdy is intend to find
out wether there is a relationship between pancreatic p cell dysfunction and lipid
profile in individu with normal glucose tolerance.
Metode: A cross sectional study was conduct to 32 individu with normal glucose
tolerance. Spearman test was conduct to assess the correlation between HOMA-B
and lipid profile.
Result: From 32 sample, we found a significant relationship between pancreatic p
cell function with total cholesterol (r:-0,601; p:0,0001) and LDL (r:-0,555;
p:0,001), which meant that the increased of total cholesterol and LDL followed
by the decreased of pancreatic p cell function. There is no significant relation
between pancreatic B cell function with I{DL and TG in this study-
Conclusion: A relationship be found between pancreatic p cell function with total
cholesterol and LDL. There is no significant relation between pancreatic B cell
function with HDL and TG. This founding showed that total cholesterol and LDL
could be used as an early predictor of pancreatic p cell dysfunction | en_US |
