| dc.description.abstract | The development of cosmetics is growing rapidly over time, especially serum
preparations as anti-aging. Serum is a preparation with highly concentrated active
substances that have the ability to penetrate deeper into the skin to deliver active
substances into the skin. Carboxymethyl chitosan has more carboxyl groups so that
hydrogen bonds with water molecules occur, so that it is able to bind water more
strongly which has the potential to maintain facial skin moisture, and is also antiaging.
Nanogold is widely studied in the cosmetic field because it is able to
overcome aging and has the ability to inhibit bacterial activity. The purpose of this
study was to formulate and evaluate gel serum preparations containing nanogold
and carboxymethyl chitosan as anti-aging agents. The formulation of the serum
preparation was carried out by making a concentration of 20 ppm nanogold and
0.25% carboxymethyl chitosan concentration which was then mixed with a serum
base. Evaluation of serum gel preparations containing nanogold and carboxymethyl
chitosan includes stability test, pH test, homogeneity test, viscosity test, irritation
test, Anti-aging effectiveness test (moisture, evenness, pores, spot, wrinkles),
antioxidant test, and anti-bacterial test. . The results of the evaluation of serum
preparations were found to be stable in storage for 4 weeks at room temperature, pH
6,38-6,36; homogeneous, viscosity 99.51 mPa.s; does not irritate the skin. The
anti-aging effectiveness of serum preparations provides percent moisture recovery
63.04%-94.87%, evenness 60%-77.78%, spot 82.54%-90%, pores 33.33%-58.97%,
and wrinkles 60%-77.78%, the percentage of inhibition was 87.2%, and the
inhibition zone for S. aureus and P.acnes bacteria with the optimum value were 20.3
mm and 14,5 mm. Thus it can be concluded that nanogold and carboxymethyl
chitosan as anti-aging can be formulated into facial serum cosmetic preparations | en_US |
