Formulasi Sediaan Serum Gel yang Mengandung Nanogold dan Kitosan Oligosakarida sebagai Antioksidan

Abstract

Serum is very interesting to be applied in cosmetic products because the active substances contained in the serum are more so that the serum is faster and more effective in dealing with skin problems. Skin aging is a dermatological change that is generally caused by aging or exposure to ultraviolet (UV) radiation. Compounds that can capture free radicals are antioxidants. Antioxidants can be used to protect the skin from damage and can prevent skin aging. Chitosan oligosaccharides are known to have potential as antimicrobials. Gold nanoparticles are widely used in the cosmetic field because they can increase skin elasticity, increase skin metabolism and have anti-aging properties. Serum formulations are made by mixing active ingredients with additives, then evaluation of serum formulations is tested by Anti- Bacterial Test with Results for Staphylocoscus bacteria with an optimum value of 16.2 mm and for Pronionibacterium Acnes bacteria with an optimum value of 13.5 mm. Antioxidant Test 86.2%, Anti Aging with Good percentage, Viscosity Test 1.0443 cP, pH 6.34-6.37, Homogeneity Test and Constant Stability Test for 4 weeks and Irritation Test gave negative results on the parameters of the irritation reaction. Thus it can be concluded that this serum formulation can be applied to facial skin.