Pengaruh Ekstrak Daun Benalu Duku (Dendrophthoe Pentandra (L.) Miq) terhadap Kadar Glukosa Darah (KGD), Superoxide Dismutase (SOD), Malondialdehyde (MDA) dan Histopatologi Pankreas Tikus Hiperglikemia

Abstract

Diabetes mellitus is a disease that causes damage to β-pancreatic cells and is widely associated with oxidative stress due to an imbalance between oxidants and antioxidants in the body that causes the development of diabetic complications. Benalu duku leaves (Dendrophthoe pentandra (L.) Miq) are plants that have secondary metabolism, namely quercetin type flavonoids. Quercetin exerts its antioxidant effect by inhibiting the production of lipid peroxides such as MDA and triggering the production of endogenous antioxidants such as SOD in NA and STZ-induced diabetic mice. This study aims to assess and analyze the effect of benalu duku leaf extract (Dendrophtoe Pentandra (L.) Miq) on decreased blood glucose levels (KGD), increased levels of superoxide dismutase (SOD), decreased levels of malondialdehyde (MDA), and repair of pancreas β cells in diabetic mice induced nicotinamide and streptozotosin. This study used 24 mice divided into 6 groups. The EEDBD dose used in this study was 100, 200, dn 400 mg/Kg BB, Glibenclamide 0.45 mg/Kg BB was used as a positive control and CMC Na as a negative control, the normal group used in this study. Diabetic rats are given benalu duku leaf extract every day. Blood glucose levels were measured on days 4, 8, 12, 16, 20, 24, and 28, while measurements of SOD, MDA and Histopathology levels were carried out on the 28th day. The results of statistical analysis showed that the administration of EEDBD doses of 400, 200, and 100 mg/Kg BB could significantly reduce KGD compared to the negative control group. Administration of EEDBD 400, 200 and 100 mg/Kg BB was able to lower MDA levels and increase SOD levels in nicotinamide and streptozotocin-induced mice. Administration of EEDBD doses of 400, 200 and 100 mg/Kg BB was able to improve the histopathological picture of the pancreas and increase the surface area of home Langerhans diabetic rats induced nicotinamide and streptozotocin.