| dc.description.abstract | Diabetes mellitus is a disease that causes damage to β-pancreatic cells and
is widely associated with oxidative stress due to an imbalance between oxidants
and antioxidants in the body that causes the development of diabetic
complications. Benalu duku leaves (Dendrophthoe pentandra (L.) Miq) are plants
that have secondary metabolism, namely quercetin type flavonoids. Quercetin
exerts its antioxidant effect by inhibiting the production of lipid peroxides such as
MDA and triggering the production of endogenous antioxidants such as SOD in
NA and STZ-induced diabetic mice. This study aims to assess and analyze the
effect of benalu duku leaf extract (Dendrophtoe Pentandra (L.) Miq) on decreased
blood glucose levels (KGD), increased levels of superoxide dismutase (SOD),
decreased levels of malondialdehyde (MDA), and repair of pancreas β cells in
diabetic mice induced nicotinamide and streptozotosin.
This study used 24 mice divided into 6 groups. The EEDBD dose used in
this study was 100, 200, dn 400 mg/Kg BB, Glibenclamide 0.45 mg/Kg BB was
used as a positive control and CMC Na as a negative control, the normal group
used in this study. Diabetic rats are given benalu duku leaf extract every day.
Blood glucose levels were measured on days 4, 8, 12, 16, 20, 24, and 28, while
measurements of SOD, MDA and Histopathology levels were carried out on the
28th day.
The results of statistical analysis showed that the administration of EEDBD
doses of 400, 200, and 100 mg/Kg BB could significantly reduce KGD compared
to the negative control group. Administration of EEDBD 400, 200 and 100 mg/Kg
BB was able to lower MDA levels and increase SOD levels in nicotinamide and
streptozotocin-induced mice. Administration of EEDBD doses of 400, 200 and
100 mg/Kg BB was able to improve the histopathological picture of the pancreas
and increase the surface area of home Langerhans diabetic rats induced
nicotinamide and streptozotocin. | en_US |
